Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta
نویسندگان
چکیده
منابع مشابه
Molecular origins for the dominant negative function of human glucocorticoid receptor beta.
This study molecularly elucidates the basis for the dominant negative mechanism of the glucocorticoid receptor (GR) isoform hGRbeta, whose overexpression is associated with human glucocorticoid resistance. Using a series of truncated hGRalpha mutants and sequential mutagenesis to generate a series of hGRalpha/beta hybrids, we find that the absence of helix 12 is neither necessary nor sufficient...
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Inflammatory responses in many cell types are coordinately regulated by the opposing actions of NF-kB and the glucocorticoid receptor (GR). The human glucocorticoid receptor (hGR) gene encodes two protein isoforms: a cytoplasmic alpha form (GRa), which binds hormone, translocates to the nucleus, and regulates gene transcription, and a nuclear localized beta isoform (GRb), which does not bind kn...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2003
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.23.12.4319-4330.2003